Willie came to the clinic complaining of erectile dysfunction. He wanted to be prescribed Viagra. However, Gregory House noticed that his shoes were way too tight, indicating they were probably insensitive, a key indicator of diabetes mellitus. He also noted powdered sugar on his sleeve, meaning he had been eating donuts and therefore was not watching his blood sugar. Dr. House reminded him erectile dysfunction is a common symptom of uncontrolled blood sugar in diabetics. However, he prescribed him the Viagra anyway.
In British English "willie" is a common euphemism for penis.
For a similar reference, see Randy