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The Ward's residents are:
- Gregory House - a famous physician suffering from psychosis and antisocial personality disorder.
- Alvie - House's roommate, suffering from bipolar disorder
- Stomp- An African-American male patient who is uncommunicative
- Jay-Bird - An African-American male with severe claustrophobia
- Richter - A Caucasian male patient with paranoid delusions that he is being tracked by the CIA
- Susan - A Caucasian female patient who survived a suicide attempt.
- Steve/Freedom Master - A Caucasian male patient suffering from delusions that he has super-powers as a result of post-traumatic stress disorder
- Annie "Silent Girl" Bohm - A Caucasian female patient who is completely unresponsive.
- Diane - A Caucasian female who is considering electro-convulsive therapy
- Hal Connor - A Caucasian male suffering from anorexia nervosa