These House, M.D. actors have also appears on one or more of the many incarnations of the Star Trek franchise
Across several series
- Kurtwood Smith
- Federation President in Star Trek VI
- Thrax on DS9
- Annorax on Voyager
- Peter Weller
- John Frederick Paxton on Enterprise
- Adm. Alexander Marcus in Star Trek: Into Darkness
- Robert Pine
- Ambassador Lina on Voyager
- Capt. Tavin on Enterprise
- Father of Chris Pine
- Keone Young
- Buck Bokai on DS9
- Mr. Sato, the father of Linda Park's character Hoshi Sato, on Enterprise
- John Rubinstein
- Minister Kuvak and Mazarite Captain on Enterprise
- John Evansville on Voyager
The Original Series
Movie Franchise
Star Trek IV: The Voyage Home
The Next Generation
- Erika Flores - Marissa Flores in Disaster
- Thomas Knickerbocker - Johnny in Clues
- Kavi Raz - Singh in Lonely Among Us
Movie Franchise
Deep Space Nine
- Joseph Culp - Raimus in Honor Among Thieves
- Christopher J. Marcinko - A Bajoran in What You Leave Behind (the finale)
Voyager
- Jay Karnes - Lt. Ducane in Relativity
- Zoe McLellan - Crewman Tal Celes in two episodes
- Dan Butler - Steth in Vis A Vis
- Scott Alan Smith - Doyle in Repression
- Mark Harelik - Kashyk in Counterpoint
Enterprise
- Jolene Blalock - T'Pol
- Linda Park - Hoshi Sato
- Anthony Montgomery - Travis Mayweather
- Andrew Borba as Xindi-Reptilian Lieutenant (3 episodes)
- Julia Rose as Corporal McKenzie in "Anomaly"
- Alexandra Lydon as Jhamel in "The Aenar"
- David A. Kimball as Esaak in "Dear Doctor"