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Wilson introduced Dr. Spain by telling House that Spain had graduated from both Johns Hopkins University and Johns Hopkins Medical School (House was a Johns Hopkins undergraduate and attended the medical school until he was expelled). In addition, like House, Spain was also a musician, playing in a rock band.
However, House tore into Spain as a poser because of his long hair and tattoo of a Chinese character on one of his wrists. Spain said that he expected House to be more tolerant of non-conformists, but House countered that loads of people Spain's age play in bands and have Chinese character tattoos. House said real non-conformists are like Wilson and Asian students - they wear pocket protectors, study hard, and really don't care what people think about that.