Princeton General Hospital is a fictional hospital in Princeton, New Jersey. It is often mentioned in the show as another hospital in the area. It is presumed to be somewhat larger than the also fictional Princeton-Plainsboro Teaching Hospital.

In Maternity, after some babies born in PPTH were proved to be sick due to an epidemic, Lisa Cuddy directs women in labor to Princeton General.

After the bus crash in House's Head, although most of the victims were taken to PPTH, the "overflow", including Amber Volakis, were taken to Princeton General instead. Gregory House and James Wilson find her there in Wilson's Heart, the only time that Princeton General is actually shown on the show.

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