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Primary sclerosing colangitis

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Primary sclerosing colangitis

Unknown for certain, but appears to be autoimmune


Fatigue, jaundice, cirrhosis, pale stool, darkened urine

Mortality Rate

About 15%, depending on treatment


Ursodeoxycholic acid, Liver transplant

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Primary sclerosing colangitis is a serious liver disease characterized by scarring, inflammation and blockages of the bile ductsBile becomes unable to leave the liver, resulting in cirrhosis, liver failure and on occasion, liver cancer.  The condition also interferes with the absorption of several fat soluble vitamins, resulting in symptoms of malnutrition.

It is not clearly known what causes colangitis, but often arises in patients with inflammatory bowel disease and ulcerative colitis

Colangitis proceeds extremely slowly, and a patient who is developing the disease may not show symptoms for years.  It is usually diagnosed in persons between the ages of 30 and 60, and is more common in men than in women.

Sclerosing cholangitis at NIH

Primary sclerososing cholangitis at Wikipedia

Primary sclerosing cholangitis at Mayo Clinic

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