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Diagnosis is difficult as the symptoms can be subtle at first, but when they proceed to serious conditions such as nasal discharge and necrosis, these are usually blamed on other conditions. Swabs are generally inconclusive and the only definitive test is a biopsy of affected tissue.
If mucormycosis is even suspected, Amphotericin B should be started despite the risk of side effects. Waiting for confirmation usually results in the death of the patient. In addition, the disease usually forms a fungal ball which should be removed surgically. Even patients who recover must be monitored carefully for signs of re-occurrence.
If the infection only affects the sinuses, the prognosis is about 70% survival. However, once it spreads to other organs, the mortality rate rises sharply and the survival rate is only about 30%.