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When the doctors thought Jessica had a metabolic disease that could be controlled with diet and exercise, Mrs. Simms insisted that Jessica did exercise and stuck to her existing diet.
However, Mrs. Simms was shocked when Jessica admitted to diet pills.
However, House soon realized that although both of Jessica's parents were above average weight, they were also both of above average height while Jessica was of below average height for her age despite her weight. They started a new differential diagnosis and realized her weight might be due to Cushing's disease.