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McLeod Syndrome

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McLeod Syndrome



Faulty gene on X chromosome responsible for construction of red blood cells.


Peripheral neuropathy, cardiomyopathy, anemia, chorea, facial tics, seizure, dementia

Mortality Rate

Inevitably fatal


Treatment of symptoms

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McLeod Syndrome is a genetic disease where the gene that codes for the proteins on the surfaces of red blood cells is faulty. It eventually leads to difficulties with the blood, brain, peripheral nerves, muscles and/or heart.

Symptoms generally start to appear when a patient is in their fifties. The disease is progressive and terminal, usually leading to death when a patient is in their sixties. Symptoms can be mild, but often progress to dementia or other changes in behavior. The disease is usually worse in males as females with a normal X-chromosome will have a normal gene that will offset the effect of the faulty gene.

There is no treatment or cure for McLeod Syndrome. Patients are treated according to their symptoms and may be given palliative care.

McLeod syndrome at Wikipedia

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