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Moriarty revealed to House that his own wife committed suicide because he had had an affair and House had asked Moriarty about it and kept pestering him until he admitted it. They cured his wife, it had nothing to do with the affair. But for no particular reason, House told her about the affair. She couldn't live with herself knowing that, so she locked herself in the garage and turned the car on, resulting in her death. When Moriarty was talking to House about what would happen if House died, he had another hallucination where he was sitting beside Moriarty's wife when she died and he saw Judy as well.