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- Jeffrey Reilich - the father of the patient in Cursed.
- Jeff Forster - A cyclist patient in the episode Spin.
- Jeffrey Cole - The Mormon and African American applicant in Season 4.
- Jeff - A man who tried to commit suicide in Painless.
- Jeff (nice guy) - The patient in No More Mr. Nice Guy.
- Jeffrey Keener - The comic book artist in Known Unknowns
- Jeffrey Sparkman aka Nurse Jeffrey - A male nurse with an antigonistic relationship with House.
- Geoff a man who becomes suspicous that his fiance Whitney is really a virgin when she gets pregnant