House's 'Vette is a 1964 Chevrolet Corvette given to House in the episode Mob Rules as a "thank you" for concealing mob turncoat Joey Arnello's Hepatitis C, which is generally contracted via homosexual activity or needle sharing, either of which accusation, if they had become known to Arnello's associates, would have destroyed his standing and credibility within the criminal organization to which he belonged.
House and Wilson find the 'Vette in House's parking spot in place of House's car. After some initial skepticism on Wilson's part, he rapidly falls in line with House's facile rationalizations for keeping the gift. House and Wilson later enjoy a night out driving the 'Vette, during which Wilson offers views on gear selection which differ from House's and which are promptly overruled and ignored.
The 'Vette vanishes after this episode and is never seen or referred to again.