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Granuloma are nodules created by bunches of macrophages in an inflammatory response to their inability to destroy foreign substances. When they are drawn to the affected area, they are surrounded by polymorphonuclear leukocytes, other immune cells and fibroblasts. They are found in many conditions from tuberculosis to fungal infections and have many different presentations including dental granuloma, foreign body granuloma and even swimming pool granuloma.

In House, they have been part of diagnoses of chronic granulomatous disease and sarcoidosis.

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