Giant-cell carcinoma of the lung is a rare type of lung cancer. It is characterized by cells that are far larger than those found in typical lung carcinomas and often contain multiple nucleii as smaller cells fuse together. Fewer than 900 cases are reported in a typical year out of about 220,000 lung cancers, and it appears in about three out of every million people in a given population. In almost every case, patients are heavy smokers and the majority of patients are male.
The main complication of the disease is its tendency to mestasticize to the small intestine, causing blockages and severe bleeding. It also frequently affects the bones, adrenal gland, brain, liver and kidneys. It frequently cases paraneoplastic syndrome.
The prognosis for a patient diagnosed with the condition is poor. Due to the rarity of the condition, there is no established treatment protocol.