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Factor V (pronounced "factor five") is a protein involved in clotting. Unlike many other proteins involved in clotting, Factor V is not an enzyme, but instead binds to other clotting factors in the presence of certain other enzymes.
The role of Factor V in clotting was not understood until well after the four other clotting factors were identified in 1905. The first paper to describe Factor V was not published until 1947 and the protein wasn't fully described until 1987.