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Cruz is usually trying to get Master's roommate Donovan to spend time with him and usually asks Masters along as well to make it look like he doesn't have an ulterior motive. He likes to make fun of the fact Masters doesn't socialize much. He also has a habit of making allusions to The Silence of the Lambs.
During Masters' last day as a medical student, as she desperately tries to do one last lumbar puncture to meet her practical requirement, Cruz does two of them just to block her even though he has done more than he has to meet his own practical requirement.