|First Appearance||Guardian Angels|
Connie first appears sitting next to Irene's bedside trying to comfort her as Irene complains about how incompetent the doctors are. The audience sees Irene's hallucination and believes that Irene is having a conversation with her. However, when the doctors ask who she's talking to, they soon realize she's hallucinating.
House starts to believe that Irene might have a genetic illness as her mother died very young. He starts asking Irene about her mother's health and learns that she lost her co-ordination before she had to go to the hospital.
However, it turns out Irene has ergot poisoning. Once she is treated, she still has hallucinations, but realizes that they are hallucinations.