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An anti-pyretic is any pharmaceutical used for the purpose of lowering the body temperature of a person with a fever. Anti-pyretics work by suppressing interleukin, the hormone that directs the hypothalmus to raise body temperature. However, in most cases, physicians will use physical means, such as cooling blankets and ice to treat severe fever.

All the commonly used analgesic drugs, aspirin, ibuprofen and acetaminophen work to reduce fever as well as pain and are appropriate for treating mild fevers. Ibuprofen is recommended for children as aspirin risks Reye's syndrome and acetaminophen has less of an anti-pyretic effect on children.

Other pharmaceuticals used as anti-pyretics are metamizole, nabumetone, nimesulide, phenazone and quinine.

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